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Magnetic properties of polyvinyl alcohol and doxorubicine loaded iron oxide nanoparticles for anticancer drug delivery applications

Nadeem, M. and Ahmad, M. and Akhtar, M. S. and Shaari, A. and Riaz, S. and Naseem, S. and Masood, M. and Saeed, M. A. (2016) Magnetic properties of polyvinyl alcohol and doxorubicine loaded iron oxide nanoparticles for anticancer drug delivery applications. PLoS ONE, 11 (6). ISSN 1932-6203

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Abstract

The current study emphasizes the synthesis of iron oxide nanoparticles (IONPs) and impact of hydrophilic polymer polyvinyl alcohol (PVA) coating concentration as well as anticancer drug doxorubicin (DOX) loading on saturation magnetization for target drug delivery applications. Iron oxide nanoparticles particles were synthesized by a reformed version of the co-precipitation method. The coating of polyvinyl alcohol along with doxorubicin loading was carried out by the physical immobilization method. X-ray diffraction confirmed the magnetite (Fe3O4) structure of particles that remained unchanged before and after polyvinyl alcohol coating and drug loading. Microstructure and morphological analysis was carried out by transmission electron microscopy revealing the formation of nanoparticles with an average size of 10 nm with slight variation after coating and drug loading. Transmission electron microscopy, energy dispersive, and Fourier transform infrared spectra further confirmed the conjugation of polymer and doxorubicin with iron oxide nanoparticles. The room temperature superparamagnetic behavior of polymer-coated and drug-loaded magnetite nanoparticles were studied by vibrating sample magnetometer. The variation in saturation magnetization after coating evaluated that a sufficient amount of polyvinyl alcohol would be 3 wt. % regarding the externally controlled movement of IONPs in blood under the influence of applied magnetic field for in-vivo target drug delivery.

Item Type:Article
Uncontrolled Keywords:doxorubicin, magnetite, polyvinyl alcohol, ultrasmall superparamagnetic iron oxide, antineoplastic antibiotic, doxorubicin, ferric ion, ferric oxide, magnetite nanoparticle, polyvinyl alcohol, Article, chemical modification, drug coating, drug delivery system, infrared spectroscopy, magnetic field, nanotechnology, particle size, structure analysis, transmission electron microscopy, X ray diffraction, chemistry, magnetic field, Antibiotics, Antineoplastic, Doxorubicin, Ferric Compounds, Magnetic Fields, Magnetite Nanoparticles, Polyvinyl Alcohol
Subjects:Q Science > QC Physics
Divisions:Science
ID Code:72516
Deposited By: Haliza Zainal
Deposited On:27 Nov 2017 11:58
Last Modified:27 Nov 2017 11:58

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