Universiti Teknologi Malaysia Institutional Repository

Feasibility of A-mode ultrasound attenuation as a monitoring method of local hyperthermia treatment

Manaf, N. A. and Aziz, M. N. C. and Ridzuan, D. S. and Mohamad Salim, M. I. and Wahab, A. A. and Lai, K. W. and Hum, Y. C. (2016) Feasibility of A-mode ultrasound attenuation as a monitoring method of local hyperthermia treatment. Medical and Biological Engineering and Computing, 54 (6). pp. 967-981. ISSN 0140-0118

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Abstract

Recently, there is an increasing interest in the use of local hyperthermia treatment for a variety of clinical applications. The desired therapeutic outcome in local hyperthermia treatment is achieved by raising the local temperature to surpass the tissue coagulation threshold, resulting in tissue necrosis. In oncology, local hyperthermia is used as an effective way to destroy cancerous tissues and is said to have the potential to replace conventional treatment regime like surgery, chemotherapy or radiotherapy. However, the inability to closely monitor temperature elevations from hyperthermia treatment in real time with high accuracy continues to limit its clinical applicability. Local hyperthermia treatment requires real-time monitoring system to observe the progression of the destroyed tissue during and after the treatment. Ultrasound is one of the modalities that have great potential for local hyperthermia monitoring, as it is non-ionizing, convenient and has relatively simple signal processing requirement compared to magnetic resonance imaging and computed tomography. In a two-dimensional ultrasound imaging system, changes in tissue microstructure during local hyperthermia treatment are observed in terms of pixel value analysis extracted from the ultrasound image itself. Although 2D ultrasound has shown to be the most widely used system for monitoring hyperthermia in ultrasound imaging family, 1D ultrasound on the other hand could offer a real-time monitoring and the method enables quantitative measurement to be conducted faster and with simpler measurement instrument. Therefore, this paper proposes a new local hyperthermia monitoring method that is based on one-dimensional ultrasound. Specifically, the study investigates the effect of ultrasound attenuation in normal and pathological breast tissue when the temperature in tissue is varied between 37 and 65 °C during local hyperthermia treatment. Besides that, the total protein content measurement was also conducted to investigate the relationship between attenuation and tissue denaturation level at different temperature ranges. The tissues were grouped according to their histology results, namely normal tissue with large predominance of cells (NPC), cancer tissue with large predominance of cells (CPC) and cancer with high collagen fiber content (CHF). The result shows that the attenuation coefficient of ultrasound measured following the local hyperthermia treatment increases with the increment of collagen fiber content in tissue as the CHF attenuated ultrasound at the highest rate, followed by NPC and CPC. Additionally, the attenuation increment is more pronounced at the temperature over 55 °C. This describes that the ultrasound wave experienced more energy loss when it propagates through a heated tissue as the tissue structure changes due to protein coagulation effect. Additionally, a significant increase in the sensitivity of attenuation to protein denaturation is also observed with the highest sensitivity obtained in monitoring NPC. Overall, it is concluded that one-dimensional ultrasound can be used as a monitoring method of local hyperthermia since its attenuation is very sensitive to the changes in tissue microstructure during hyperthermia.

Item Type:Article
Uncontrolled Keywords:Chemotherapy, Coagulation, Collagen, Computerized tomography, Diseases, Energy dissipation, Histology, Hyperthermia therapy, Image processing, Magnetic resonance imaging, Microstructure, Monitoring, Proteins, Signal processing, Ultrasonic effects, Ultrasonic imaging, Ultrasonic waves, Attenuation coefficient, Hyperthermia treatments, Local hyperthermia, Measurement instruments, Quantitative measurement, Real time monitoring system, Total protein, Ultrasound imaging systems, Tissue, collagen, protein, A scan, animal cell, animal experiment, animal model, animal tissue, Article, body temperature, breast cancer, cancer tissue, collagen fiber, controlled study, diagnostic imaging equipment, feasibility study, female, histopathology, manually controlled ultrasound pulser, mouse, nonhuman, priority journal, protein content, protein denaturation, radiation attenuation, real time echography, thermotherapy, tissue level, tissue necrosis, tissue structure, tumor necrosis, ultrasound transducer
Subjects:Q Science > QH Natural history
Divisions:Biosciences and Medical Engineering
ID Code:72462
Deposited By: Narimah Nawil
Deposited On:26 Nov 2017 11:37
Last Modified:26 Nov 2017 11:37

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