Universiti Teknologi Malaysia Institutional Repository

Empty nano and micro-structured lipid carriers of virgin coconut oil for skin moisturisation

Noor, N. M. and Khan, A. A. and Hasham, R. and Talib, A. and Sarmidi, M. R. and Aziz, R. and Abd., A. (2016) Empty nano and micro-structured lipid carriers of virgin coconut oil for skin moisturisation. IET Nanobiotechnology, 10 (4). pp. 195-199. ISSN 1751-8741

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Virgin coconut oil (VCO) is the finest grade of coconut oil, rich in phenolic content, antioxidant activity and contains medium chain triglycerides (MCTs). In this work formulation, characterisation and penetration of VCO-solid lipid particles (VCO-SLP) have been studied. VCO-SLP were prepared using ultrasonication of molten stearic acid and VCO in an aqueous solution. The electron microscopy imaging revealed that VCO-SLP were solid and spherical in shape. Ultrasonication was performed at several power intensities which resulted in particle sizes of VCO-SLP ranged from 0.608 ± 0.002 μm to 44.265 ± 1.870 μm. The particle size was directly proportional to the applied power intensity of ultrasonication. The zeta potential values of the particles were from -43.2 ± 0.28 mV to -47.5 ± 0.42 mV showing good stability. The cumulative permeation for the smallest sized VCO-SLP (0.608 μm) was 3.83 ± 0.01 μg/cm2 whereas for larger carriers it was reduced (3.59 ± 0.02 μg/cm2). It is concluded that SLP have the potential to be exploited as a micro/nano scale cosmeceutical carrying vehicle for improved dermal delivery of VCO.

Item Type:Article
Uncontrolled Keywords:Particle size, Solutions, Vegetable oils, Anti-oxidant activities, Lipid particles, Medium chain triglycerides, Phenolic content, Potential values, Structured lipids, Ultra-sonication, Virgin coconut oil, Variable frequency oscillators, coconut oil, liposome, microcapsule, nanocapsule, skin cream, vegetable oil, absorption, administration and dosage, animal, chemistry, cutaneous drug administration, drug effects, drug formulation, drug stability, in vitro study, materials testing, microcapsule, particle size, physiology, procedures, rat, skin absorption, thermoregulation, ultrastructure, Absorption, Physicochemical, Administration, Cutaneous, Animals, Capsules, Drug Compounding, Drug Stability, In Vitro Techniques, Liposomes, Materials Testing, Nanocapsules, Particle Size, Plant Oils, Rats, Skin Absorption, Skin Cream, Water Loss, Insensible
Subjects:T Technology > TP Chemical technology
Divisions:Chemical Engineering
ID Code:72235
Deposited By: Fazli Masari
Deposited On:21 Nov 2017 08:17
Last Modified:21 Nov 2017 08:17

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