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Fabrication and hemocompatibility assessment of novel polyurethane-based bio-nanofibrous dressing loaded with honey and Carica papaya extract for the management of burn injuries

Balaji, A. and Jaganathan, S. K. and Ismail, A. F. and Rajasekar, R. (2016) Fabrication and hemocompatibility assessment of novel polyurethane-based bio-nanofibrous dressing loaded with honey and Carica papaya extract for the management of burn injuries. International Journal of Nanomedicine, 11 . pp. 4339-4355. ISSN 1176-9114

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Abstract

Management of burn injury is an onerous clinical task since it requires continuous monitoring and extensive usage of specialized facilities. Despite rapid improvizations and investments in burn management, >30% of victims hospitalized each year face severe morbidity and mortality. Excessive loss of body fluids, accumulation of exudate, and the development of septic shock are reported to be the main reasons for morbidity in burn victims. To assist burn wound management, a novel polyurethane (PU)-based bio-nanofibrous dressing loaded with honey (HN) and Carica papaya (PA) fruit extract was fabricated using a one-step electrospinning technique. The developed dressing material had a mean fiber diameter of 190±19.93 nm with pore sizes of 4-50 µm to support effective infiltration of nutrients and gas exchange. The successful blending of HN- and PA-based active biomolecules in PU was inferred through changes in surface chemistry. The blend subsequently increased the wettability (14%) and surface energy (24%) of the novel dressing. Ultimately, the presence of hydrophilic biomolecules and high porosity enhanced the water absorption ability of the PU-HN-PA nanofiber samples to 761.67% from 285.13% in PU. Furthermore, the ability of the bio-nanofibrous dressing to support specific protein adsorption (45%), delay thrombus formation, and reduce hemolysis demonstrated its nontoxic and compatible nature with the host tissues. In summary, the excellent physicochemical and hemocompatible properties of the developed PU-HN-PA dressing exhibit its potential in reducing the clinical complications associated with the treatment of burn injuries.

Item Type:Article
Uncontrolled Keywords:Carica papaya extract, nanofiber, plasma protein, polyurethan, nanofiber, plant extract, polyurethan, adsorption, adult, Article, blood clotting, blood compatibility, burn, cell adhesion, cell infiltration, cell migration, cell proliferation, cell regeneration, cell spreading, cell structure, cell viability, contact angle, controlled study, electric conductivity, electrospinning, fiber, Fourier transform infrared photoacoustic spectroscopy, gas exchange, hemolysis, honey, human, hydrophilicity, moisture, molecular interaction, nanofabrication, nutrient, partial thromboplastin time, physical chemistry, physical parameters, porosity, prothrombin time, surface energy, surface property, swelling kinetics, thermostability, viscosity, water absorption, wettability, wound dressing, wound healing, bandage, Burns, Carica, chemistry, disease management, drug effects, pathophysiology, Adsorption, Bandages, Burns, Carica, Disease Management, Hemolysis, Honey, Humans, Nanofibers, Plant Extracts, Polyurethanes, Porosity, Wound Healing
Subjects:T Technology > TP Chemical technology
Divisions:Chemical Engineering
ID Code:72103
Deposited By: Fazli Masari
Deposited On:23 Nov 2017 06:19
Last Modified:23 Nov 2017 06:19

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