Universiti Teknologi Malaysia Institutional Repository

A hyperelastic fibre-reinforced continuum model of healing tendons with distributed collagen fibre orientations

Bajuri, M. N. and Isaksson, H. and Eliasson, P. and Thompson, M. S. (2016) A hyperelastic fibre-reinforced continuum model of healing tendons with distributed collagen fibre orientations. Biomechanics and Modeling in Mechanobiology, 15 (6). pp. 1457-1466. ISSN 1617-7959

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Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

The healing process of ruptured tendons is problematic due to scar tissue formation and deteriorated material properties, and in some cases, it may take nearly a year to complete. Mechanical loading has been shown to positively influence tendon healing; however, the mechanisms remain unclear. Computational mechanobiology methods employed extensively to model bone healing have achieved high fidelity. This study aimed to investigate whether an established hyperelastic fibre-reinforced continuum model introduced by Gasser, Ogden and Holzapfel (GOH) can be used to capture the mechanical behaviour of the Achilles tendon under loading during discrete timepoints of the healing process and to assess the model’s sensitivity to its microstructural parameters. Curve fitting of the GOH model against experimental tensile testing data of rat Achilles tendons at four timepoints during the tendon repair was used and achieved excellent fits (0.9903 < R2< 0.9986). A parametric sensitivity study using a three-level central composite design, which is a fractional factorial design method, showed that the collagen-fibre-related parameters in the GOH model—κ,k1′ and k2′—had almost equal influence on the fitting. This study demonstrates that the GOH hyperelastic fibre-reinforced model is capable of describing the mechanical behaviour of healing tendons and that further experiments should focus on establishing the structural and material parameters of collagen fibres in the healing tissue.

Item Type:Article
Uncontrolled Keywords:Collagen, Constitutive models, Continuum mechanics, Curve fitting, Elasticity, Fiber reinforced materials, Fibers, Finite element method, Reinforcement, Tensile testing, Tissue, Central composite designs, Computational mechanobiology, Continuum Modeling, Fractional factorial designs, Mechanical behaviour, Microstructural parameters, Parametric sensitivity, Tendon healing, Tendons, achilles tendon, Article, collagen fiber, curve fitting, factorial design, healing, nonhuman, priority journal, rat, tendon reconstruction, tendon rupture, analysis of variance, animal, biological model, chemistry, computer simulation, elasticity, finite element analysis, pathology, tendon, tensile strength, wound healing, collagen, Analysis of Variance, Animals, Collagen, Computer Simulation, Elasticity, Finite Element Analysis, Models, Biological, Rats, Tendons, Tensile Strength, Wound Healing
Subjects:Q Science > QH Natural history
Divisions:Biosciences and Medical Engineering
ID Code:71886
Deposited By: Fazli Masari
Deposited On:23 Nov 2017 14:19
Last Modified:23 Nov 2017 14:19

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