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Drug-eluting coating of ginsenoside Rg1 and Re incorporated poly(lactic-co-glycolic acid) on stainless steel 316L: physicochemical and drug release analyses

Miswan, Z. and Lukman, S. K. and Abd Majid, F. A. and Loke, M. F. and Saidin, S. and Hermawan, H. (2016) Drug-eluting coating of ginsenoside Rg1 and Re incorporated poly(lactic-co-glycolic acid) on stainless steel 316L: physicochemical and drug release analyses. International Journal of Pharmaceutics, 515 (1-2). pp. 460-466. ISSN 0378-5173

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Active ingredients of ginsenoside, Rg1 and Re, are able to inhibit the proliferation of vascular smooth muscle cells and promote the growth of vascular endothelial cells. These capabilities are of interest for developing a novel drug-eluting stent to potentially solve the current problem of late-stent thrombosis and poor endotheliazation. Therefore, this study was aimed to incorporate ginsenoside into degradable coating of poly(lactic-co-glycolic acid) (PLGA). Drug mixture composed of ginseng extract and 10% to 50% of PLGA (xPLGA/g) was coated on electropolished stainless steel 316L substrate by using a dip coating technique. The coating was characterized principally by using attenuated total reflectance-Fourier transform infrared spectroscopy, scanning electron microscopy and contact angle analysis, while the drug release profile of ginsenosides Rg1 and Re was determined by using mass spectrometry at a one month immersion period. Full and homogenous coating coverage with acceptable wettability was found on the 30PLGA/g specimen. All specimens underwent initial burst release dependent on their composition. The 30PLGA/g and 50PLGA/g specimens demonstrated a controlled drug release profile having a combination of diffusion- and swelling-controlled mechanisms of PLGA. The study suggests that the 30PLGA/g coated specimen expresses an optimum composition which is seen as practicable for developing a controlled release drug-eluting stent.

Item Type:Article
Uncontrolled Keywords:ginseng extract, ginsenoside Re, ginsenoside Rg 1, polyglactin, stainless steel, biocompatible coated material, delayed release formulation, drug, ginsenoside, ginsenoside Re, ginsenoside Rg 1, lactic acid, polyglycolic acid, polylactic acid-polyglycolic acid copolymer, stainless steel, Article, contact angle, controlled drug release, drug coating, drug eluting stent, drug mechanism, drug mixture, drug release, immersion, infrared spectroscopy, liquid chromatography, physical chemistry, priority journal, quadrupole mass spectrometry, scanning electron microscopy, time of flight mass spectrometry, wettability, chemistry, delayed release formulation, drug eluting stent, materials testing, procedures, Coated Materials, Biocompatible, Delayed-Action Preparations, Drug Liberation, Drug-Eluting Stents, Ginsenosides, Lactic Acid, Materials Testing, Microscopy, Electron, Scanning, Pharmaceutical Preparations, Polyglycolic Acid, Spectroscopy, Fourier Transform Infrared, Stainless Steel
Subjects:R Medicine > R Medicine (General)
Divisions:Biosciences and Medical Engineering
ID Code:71502
Deposited By: Fazli Masari
Deposited On:15 Nov 2017 03:41
Last Modified:15 Nov 2017 03:41

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