Adsorption of amoxicillin on surfactant modified zeolites and their antibacterial activity

Abstract

This research was divided into three main parts: loading of HDTMA and amoxicillin on the natural clinoptilolite, characterization of the product using Fourier Transform Infrared (FTIR) spectroscopy and the antibacterial activity using minimum inhibitory concentration (MIC). IR spectra of natural zeolites, clinoptilolite and the modified ones with HDTMA and amoxicillin proved that the band position was same even at the highest surfactant loading level which suggests no changes in the structure of the samples after modification with amoxicillin and surfactant molecules (HDTMA). No changes in the peaks of the IR spectra in the regions of 3400 to 2600 cm-1 for HDTMA-zeolite were seen when compared with the respective parent zeolites. More over our results demonstrate two significant peaks at around 2849 cm-1 and 2916 cm-1 which mean that the surfactant had been successfully attached on clinoptilolite. In addition, loaded amoxicillin on SMZ did not show any special peaks due to similar groups such as C-H with HDTMAclinoptilolite. FTIR spectra of Amoxicilin-surfactantclinoptilolite and surfactant modified zeolite were same. MIC results revealed that the antibacterial activity of the modified clinoptilolite with surfactant and amoxicilin was significantly higher as compared to the parent clinoptilolite and amoxicilin alone.