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Isolation, characterization and modification of zerumbone from zingiber zerumbet

Mohamad Noor, Nur Farhanah and Mohd. Sirat, Hasnah (2016) Isolation, characterization and modification of zerumbone from zingiber zerumbet. E-Proceedings Chemistry, 1 (1). pp. 7-10. ISSN 2550-1453

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Official URL: http://eproceedings.chemistry.utm.my/index.php/FYP...

Abstract

Zingiber zerumbet Smith belongs to Zingiberaceae family. The most important part of this plant is its rhizomes which have been associated with variety of medicinal uses. Rhizome of the Zingiber Zerumbet Smith is pale yellow with pungent smell and used as traditional medicine in relieving stomach ache, as a diuretic, and when macerated in alcohols are regarded as a tonic and depurative. Hydrodistillation of the rhizome of Zingiber zerumbet yield essential oil with five major compounds which are zerumbone (79.79%), α-humulene (6.85%), camphene (1.04%), caryophyllene oxide (1.36%), and (1R,3E,7E,11R)-1,5,5,8-tetramethyl-12-oxabicyclo-9,1,0-dodeca-3,7-diene (3.24%). The soxhlet extraction method of the rhizome using n-hexane as solvent yielded pale yellow extract crude (8.45 g, 1.69%). Recrystallization of the crude yielded zerumbone as white crystal solid (0.191 g, 2.26%). The zerumbone undergo reactions with m-CPBA in dichloromethane to give zerumbone epoxide (152 mg, 89.91%). Both zerumbone and zerumbone epoxide were characterized using 1H and 13C NMR spectroscropy.

Item Type:Article
Additional Information:RADIS System Ref No:PB/2016/09539
Uncontrolled Keywords:Zingiber zerumbet, essential oil, zerumbone, zerumbone epoxide
Subjects:Q Science
Divisions:Science
ID Code:68333
Deposited By: Widya Wahid
Deposited On:28 Nov 2017 16:38
Last Modified:28 Nov 2017 16:38

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