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Methods for the determination of endocrine-disrupting phthalate esters

Qureshi, M. S. and Mohd. Yusoff, Abdull Rahim and Wirzal, Mohd. Dzul Hakim and Sirajuddin, Sirajuddin and Barek, Jiri and Hassan, Imran Afridi and Ustundag, Zafer (2016) Methods for the determination of endocrine-disrupting phthalate esters. Critical Reviews in Analytical Chemistry, 46 (2). pp. 146-159. ISSN 1040-8347

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Official URL: http://dx.doi.org/10.1080/10408347.2015.1004157


Phthalates are endocrine disruptors frequently occurring in the general and industrial environment and in many industrial products. Moreover, they are also suspected of being carcinogenic, teratogenic, and mutagenic, and they show diverse toxicity profiles depending on their structures. The European Union and the United States Environmental Protection Agency (US EPA) have included many phthalates in the list of priority substances with potential endocrine-disrupting action. They are: dimethyl phthalate (DMP), diethyl phthalate (DEP), dibutyl phthalate (DBP), butylbenzyl phthalate (BBP), diethylhexyl phthalate (DEHP), di-iso-nonyl phthalate (DINP), di-iso-decyl phthalate (DIDP), di-n-decyl phthalate (DnDP), and dioctyl phthalate (DOP). There is an ever-increasing demand for new analytical methods suitable for monitoring different phthalates in various environmental, biological, and other matrices. Separation and spectrometric methods are most frequently used. However, modern electroanalytical methods can also play a useful role in this field because of their high sensitivity, reasonable selectivity, easy automation, and miniaturization, and especially low investment and running costs, which makes them suitable for large-scale monitoring. Therefore, this review outlines possibilities and limitations of various analytical methods for determination of endocrine-disruptor phthalate esters in various matrices, including somewhat neglected electroanalytical methods.

Item Type:Article
Additional Information:RADIS System Ref No:PB/2016/05503
Subjects:Q Science
ID Code:68323
Deposited By: Haliza Zainal
Deposited On:02 Nov 2017 10:56
Last Modified:20 Nov 2017 16:52

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