Universiti Teknologi Malaysia Institutional Repository

Anticholinesterase and anti-inflammatory constituents from beilschmiedia pulverulenta kosterm

W. Salleh, Wan Mohd Nuzul Hakimi and Ahmad, Farediah and Khong, Heng Yen and Mohamed Zulkifli, Razauden (2016) Anticholinesterase and anti-inflammatory constituents from beilschmiedia pulverulenta kosterm. Natural Product Sciences, 22 (4). pp. 225-230. ISSN 1226-3907

Full text not available from this repository.

Official URL: https://doi.org/10.20307/nps.2016.22.4.1

Abstract

Phytochemical investigation from the stem bark of Beilschmiedia pulverulenta resulted in the isolation of five lignans, (+)-yangambin ( 1 ), (+)-sesartemin ( 2 ), (+)-excelsin ( 3 ), (+)-sesamin ( 4 ), and (+)-syringaresinol ( 5 ), together with lupeol ( 6 ), lupenone ( 7 ), β -sitosterol ( 8 ), and β -sitostenone ( 9 ). Their structures were established by the analysis of their spectroscopic (1D and 2D NMR) and spectrometric (MS) data, as well as by comparison with those reported in the literature. The isolated lignans were tested for their anticholinesterase (AChE: acetylcholine esterase and BChE: butyryl cholineesterase) and anti-inflammatory (COX-2: cyclooxygenase-2 and LOX: lipoxygenase) activities. All the isolated lignans ( 1 – 5 ) exhibited significant inhibition activities in AChE/BChE and COX-2/LOX assays with IC 50 values ranging from 168.8 – 504.2 μM and 21.0 – 59.4 μM, respectively.

Item Type:Article
Additional Information:RADIS System Ref No:PB/2016/08080
Subjects:Q Science
R Medicine
Divisions:Biosciences and Medical Engineering
Science
ID Code:68305
Deposited By: Haliza Zainal
Deposited On:01 Nov 2017 11:31
Last Modified:20 Nov 2017 16:52

Repository Staff Only: item control page