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Flavonoids from the leaves and heartwoods of Artocarpus lowii King and their bioactivities

Abdullah, Siti Awanis and Jamil, Shajarahtunnur and Basar, Norazah and Abdul Lathiff, Siti Mariam and Mohd. Arriffin, Norzafneza (2017) Flavonoids from the leaves and heartwoods of Artocarpus lowii King and their bioactivities. Natural Product Research, 31 (10). pp. 1113-1120. ISSN 1478-6419

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Official URL: http://dx.doi.org/10.1080/14786419.2016.1222387


A new dihydrochalcone, 2′,4′-dihydroxy-3,4-(2″,2″-dimethylchromeno)-3′-prenyldihydrochalcone (1) together with 4-hydroxyonchocarpin (2), isobavachalcone (3), 4′,5-dihydroxy-6,7-(2,2-dimethylpyrano)-2′-methoxy-8-γ,γ-dimethylallyflavone (4), artocarpin (5) and cycloheterophyllin (6) were successfully isolated from the leaves and heartwoods of Artocarpus lowii King (Moraceae). The structures of these compounds were fully characterised using spectroscopic methods and by direct comparison with published data. These compounds were tested for their antioxidant and tyrosinase inhibitory activities. Compound (1) displayed moderate antioxidant activity towards DPPH and tyrosinase inhibitory activities with SC50 value of 223.8 μM and IC50 value of 722.5 μM, respectively. Among the isolated compounds, cycloheterophyllin (6) showed the most potential antioxidant activity with SC50 value of 320.0 and 102.8 μM for ABTS and DPPH radicals scavenging activities, respectively, and also exhibited highest FRAP equivalent value of 4.7 ± 0.09 mM. Compound (6) showed tyrosinase inhibitory activity with the IC50 value of 104.6 μM.

Item Type:Article
Additional Information:RADIS System Ref No:PB/2016/04300
Uncontrolled Keywords:antioxidant, tyrosinase inhibitory activity
Subjects:Q Science
ID Code:66522
Deposited By: Fazli Masari
Deposited On:03 Oct 2017 21:50
Last Modified:03 Oct 2017 21:50

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