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Cytotoxicity of triterpenes from the leaves of Garcinia Prainiana King (Guttiferae)

On, Shamsul and W. Salleh, Wan Mohd Nuzul Hakimi and Ahmad, Farediah and Mohd Sirat, Hasnah and Taher, Muhammad (2017) Cytotoxicity of triterpenes from the leaves of Garcinia Prainiana King (Guttiferae). Marmara Pharmaceutical Journal, 21 (1). pp. 127-131. ISSN 1309-0801

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Official URL: http://dx.doi.org/10.12991/marupj.259890


Phytochemical investigation of the leaves of Garcinia prainiana resulted in the isolation of five triterpenes identified as squalene 1, friedelin 2, lupeol 3, 3β-hydroxyeupha-5,22-diene 4, and 3β-acetoxyeupha-5,22-diene 5. The structures of these compounds were established by analysis of their spectroscopic data, as compared to that of reported compounds. All compounds were tested for cytotoxicity against H1299 and A549 lung cancer cell lines using MTT assay. 3β-Acetoxyeupha-5,22-diene 5 exhibited the most significant activity against human non-small cell lung carcinoma cell lines, H1299 and A549 with IC50 values 18.0 μg/mL and 36.3 μg/mL, respectively.

Item Type:Article
Additional Information:RADIS System Ref No:PB/2017/11423
Uncontrolled Keywords:triterpene, garcinia prainiana
Subjects:Q Science
ID Code:66123
Deposited By: Widya Wahid
Deposited On:11 Jul 2017 15:40
Last Modified:11 Jul 2017 15:40

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