Development and evaluation of nanoemulsion hydrogel

Abstract

New methods of drug delivery can now be used to increase the effectiveness and safety of medication. Therefore, several new drug carrier systems have been developed such as nanoemulsions Nanoemulsion is submicron sized emulsion Typically in the range of 20-200 cm, Avocado oil is often used in herbal skin care. The aim of this study was to characterize nanoemulsion hydrogel prepared using avocado oil and sucrose ester stearate as surfactant. The nanoemulsion hydrogel were prepared by nanophase emulsification technique. These forrnulations were examined using zetasizer to determined the mean diameter of dispersed oil droplets, polydispersibility index (PD1) and zeta potential. Also the viscosity of the prepared nanoemulslon hydrogel were studied. The results reveled that nanoemulson prepared with 60% w/w oil, 24% w/w glycerol and 16%w/w surfactant showed droplets size below 200 nm with good polydispersibility index and zeta potential < -30 mV. The optimum formulation of nanoemulsion was prepared in the form of nanoemulsion hydrogel using cerbopols 934 and 940. The results of the viscometer for the nanoemulsion hydrogel showed that the storaqe modulus (G') which describes the elasticity of the component were greater than the loss modulus (G") values which reveals the viscosity of the component.