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Tyrosinase inhibitory activity of flavonoids from artocarpus lowii king

Jamil, Shajarahtunnur and Abdullah, Siti Awanis and Abdul Lathiff, Siti Mariam and Mohd. Sirat, Hasnah (2014) Tyrosinase inhibitory activity of flavonoids from artocarpus lowii king. Jurnal Teknologi, 71 (1). pp. 55-58. ISSN 0127-9696

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Official URL: http://dx.doi.org/10.11113/jt.v71.2711

Abstract

Tyrosinase inhibitory activity was studied on the crude extracts and flavonoids successfully isolated from the leaves and heartwoods of Artocarpus lowii King. The flavonoids were fully characterized spectroscopically as isobavachalcone (1), 4-hydroxyonchocarpin (2), 2',4'-dihydroxy-4-methoxy-3'- prenyldihydrochalcone (3), 2',4'-dihydroxy-3,4-(2",2"-dimethylchromeno)-3'-prenyldihydrochalcone (4), artocarpin (5), cycloheterophyllin (6) and 4',5-dihydroxy-6,7-(2,2-dimethylpyrano)-2'-methoxy-8-γ,γ- dimethyl allylflavone (7). Tyrosinase inhibitory activity of the samples was determined against mushroom tyrosinase using ELISA microplate reader. Cycloheterophyllin (6) exhibited an excellent inhibitory activity against mushroom tyrosinase comparable to the standard kojic acid with the IC50 value of 52.5 μg/mL (88.3%).

Item Type:Article
Uncontrolled Keywords:artocarpus lowii, flavonoid
Subjects:Q Science
Divisions:Science
ID Code:63146
Deposited By: Siti Nor Hashidah Zakaria
Deposited On:15 Jun 2017 10:00
Last Modified:15 Jun 2017 10:00

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