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Triple-layered PLGA/nanoapatite/lauric acid graded composite membrane for periodontal guided bone regeneration

Jamuna-Thevi, Kalitheertha and Saarani, Nur Najiha Ajiha and Abdul Kadir, Mohammed Rafiq and Hermawan, Hendra (2014) Triple-layered PLGA/nanoapatite/lauric acid graded composite membrane for periodontal guided bone regeneration. Materials Science and Engineering C, 43 . pp. 253-263. ISSN 0928-4931

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Official URL: http://dx.doi.org/10.1016/j.msec.2014.07.028

Abstract

This paper discusses the successful fabrication of a novel triple-layered poly(lactic-co-glycolic acid) (PLGA)-based composite membrane using only a single step that combines the techniques of solvent casting and thermally induced phase separation/solvent leaching. The resulting graded membrane consists of a small pore size layer-1 containing 10 wt% non-stoichiometric nanoapatite (NAp) + 1-3 wt% lauric acid (LA) for fibroblastic cell and bacterial inhibition, an intermediate layer-2 with 20-50 wt% NAp + 1 wt% LA, and a large pore size layer-3 containing 30-100 wt% NAp without LA to allow bone cell growth. The synergic effects of 10-30 wt% NAp and 1 wt% LA in the membrane demonstrated higher tensile strength (0.61 MPa) and a more elastic behavior (16.1% elongation at break) in 3 wt% LA added membrane compared with the pure PLGA (0.49 MPa, 9.1%). The addition of LA resulted in a remarkable plasticizing effect on PLGA at 3 wt% due to weak intermolecular interactions in PLGA. The pure and composite PLGA membranes had good cell viability toward human skin fibroblast, regardless of LA and NAp contents.

Item Type:Article
Uncontrolled Keywords:solvent casting, solvent leaching
Subjects:Q Science > QH Natural history
Divisions:Biosciences and Medical Engineering
ID Code:63131
Deposited By: Siti Nor Hashidah Zakaria
Deposited On:15 Jun 2017 09:50
Last Modified:15 Jun 2017 09:50

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