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Surface modification of yttria stabilized zirconia via polydopamine inspired coating for hydroxyapatite biomineralization

Muhamad Zain, Norhidayu and Hussain, Rafaqat and Abdul Kadir, Mohammed Rafiq (2014) Surface modification of yttria stabilized zirconia via polydopamine inspired coating for hydroxyapatite biomineralization. Applied Surface Science, 322 . pp. 169-176. ISSN 0169-4332

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Official URL: http://dx.doi.org/10.1016/j.apsusc.2014.09.179

Abstract

Yttria stabilized zirconia (YSZ) has been widely used as biomedical implant due to its high strength and enhanced toughening characteristics. However, YSZ is a bioinert material which constrains the formation of chemical bonds with bone tissue following implantation. Inspired by the property of mussels, the surface of YSZ ceramics was functionalized by quinone-rich polydopamine to facilitate the biomineralization of hydroxyapatite. YSZ discs were first immersed in 2 mg/mL of stirred or unstirred dopamine solution at either 25 or 37 degrees C. The samples were then incubated in 1.5 simulated body fluid (SBF) for 7d. The effect of coating temperature for stirred and unstirred dopamine solutions during substrate grafting was investigated on the basis of chemical compositions, wettability and biomineralization of hydroxyapatite on the YSZ functionalized surface. The results revealed that the YSZ substrate grafted at 37 degrees C in stirred solution of dopamine possessed significantly improved hydrophilicity (water contact angle of 44.0 +/- 2.3) and apatite-mineralization ability (apatite ratio of 1.78). In summary, the coating temperature and stirring condition during grafting procedure affected the chemical compositions of the films and thus influenced the formation of apatite layer on the substrate during the biomineralization process.

Item Type:Article
Uncontrolled Keywords:polydopamine, biomineralization
Subjects:Q Science > QH Natural history
Divisions:Biosciences and Medical Engineering
ID Code:62735
Deposited By: Fazli Masari
Deposited On:05 Jun 2017 11:08
Last Modified:05 Jun 2017 11:08

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