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Synthesis of 2'-hydroxy-4'-O-prenylchalcones

Mohd. Fauzi, Nur Edelin and Ahmad, Farediah (2015) Synthesis of 2'-hydroxy-4'-O-prenylchalcones. In: International Conference on Natural Products 2015, 24-25 March, 2015, Johor Bahru, Johor.

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Abstract

A facile method has been applied to synthesis 4' -O-prenychalcones through Claisen-Schmidt condensation between prenylated acetophenone and benzaldehyde derivatives giving chalcone s 1-5. The structures of the compounds were verified through spectroscopic methods; NMR and IR spectroscopies. These compounds are; 2'-hydroxy-4-(N,Ndimethyl) amino-4'-0-prenylc halcone (1), 2'-hydroxy-2-methox y-4' -O-prenylchalcone (2), 2'hydroxy- 4-isopropyl-4' -O-prenylchalcone (3), 2'-hydroxy-3,4-dimethoxy-4'-0prenylchalcone (4) and 2'-hydroxy-4-nitro-4'-0-prenylchalcone (5). The compounds were later subjec ted to antibacteria l activities using micro-dilution method against Gram-positive and Gram-nega tive bacteria.

Item Type:Conference or Workshop Item (Paper)
Uncontrolled Keywords:spectroscopic methods, micro-dilution method
Subjects:Q Science > QD Chemistry
Divisions:Science
ID Code:62285
Deposited By: Widya Wahid
Deposited On:16 May 2017 00:57
Last Modified:31 Jul 2017 07:49

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