Universiti Teknologi Malaysia Institutional Repository

Analysis of tumor growth and immune system interaction model

Awang, Nor Aziran and Maan, Normah (2015) Analysis of tumor growth and immune system interaction model. In: Simposium Kebangsaan Sains Matematik 23, 24-26 Nov, 2015, Skudai, Johor.

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Official URL: http://science.utm.my/sksm23/

Abstract

Immune system plays a vital role in controlling the tumor growth. Therefore, this paper proposes a new mathematical model that describes tumor-immune interaction, focusing on the role of natural killer (NK) cell and CD8+ T cell. The tumor population is subdivided into two different phases, namely interphase and mitosis. This model used Ordinary Differential Equations (ODEs) and the functions involved in the model represents tumor-immune growth, responses and interaction between the cells. The stability and analysis of the model are carried out. From the analysis, it shown that the stability curve limits tumor growth region. The curve from the model lie below the curve of the model with single immune response (CD8+ T cell). This result concluded that the proposed model with involvement of NK cell suppression will lower the tumor growth region.

Item Type:Conference or Workshop Item (Paper)
Uncontrolled Keywords:tumor growth, natural killer
Subjects:Q Science > QA Mathematics
Divisions:Science
ID Code:61783
Deposited By: Fazli Masari
Deposited On:26 Apr 2017 06:32
Last Modified:26 Apr 2017 06:32

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