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In vitro antiviral activity of aqueous extracts of polygonum minus huds leaves against herpes simplex virus 1

Shahar, Saleha and Hamdan, Salehhuddin and Baba, Sayang and Paul Joko, Alvin Dickson (2015) In vitro antiviral activity of aqueous extracts of polygonum minus huds leaves against herpes simplex virus 1. In: 29th Scientific Meeting of Malaysian Society of Pharmacology and Physiology (MSPP), 24-25 Aug, 2015, Selangor, Malaysia.

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Official URL: https://medicine.uitm.edu.my/mspp2015/

Abstract

Polygonum minus (P. minusi extract was investigated as a potential antiviral agent against herpes simplex virus I (HSY- I). Cell survival to assess antiviral activity was detrmined via MTT and crystal violet assays. Initially, cytotoxicity for minimal non-toxic dose was determined prior to MIT assay. The HSY-l was infected at 1.00 MOl into Vero cells and the cytopathic effect was observed by inverted microscopy. Antiviral treatment was performed based on a time-of-addition routine; simultaneous-treatment, pre-treatment and post-treatment for 24 hours incubation. Aqueous extract was found to be effective in inhibiting HSY-I in post-treatment, mildly effective in pre-treatment and not effective in simultaneous treatment. In conclusion, aqueous extract of P. minus could be a potential candidate for anti-HSV-I activity. Indeed, further studies are required before a conclusive experimental finding be suggested.

Item Type:Conference or Workshop Item (Paper)
Uncontrolled Keywords:simultaneous-treatment, crystal violet assays
Subjects:R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
Divisions:Biosciences and Medical Engineering
ID Code:61497
Deposited By: Widya Wahid
Deposited On:25 Apr 2017 12:14
Last Modified:25 Apr 2017 12:14

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