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Cotton thread for size-based blood cells sorting

Yazdani, Fahimeh and Sadir, Sahba and Huyop, Fahrul Zaman and Bagus Wicaksono, Dedy Hermawan (2015) Cotton thread for size-based blood cells sorting. In: Advanced Materials Research, 24-28 Sept, 2015, Indonesia.

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Official URL: https://www.scientific.net/AMR.1112.437


We proposed cotton thread as a low cost platform for fabricating size-based cell sorting microfluidic chip. The cells and beads can be wicked through 3D structures of thread via capillary forces without any external forces. However, the major mechanism of capturing cell inside of thread was mechanical entrapment inside the gaps between the fibers. Cells sorting property based on their size was tuned by using multiple threads having different twist per inch (TPI). The fabricated device has 3 different zones from the inlet to the outlet where each zone has a different TPI which means different sizes of gaps. The results showed that small beads were trapped in thread which has more TPI and smaller gaps, while bigger beads were trapped in thread with less TPI and larger gaps. For proof of concept, blood as a complex mixture of cells with wide range of size was wicked into the fabricated device. The result showed efficient separation of red blood cells, white blood cells and plasma. The capability of cotton threads as a proper material for fabrication of size based cell sorting microfluidic devices was proved with higher simplicity and efficiency.

Item Type:Conference or Workshop Item (Paper)
Uncontrolled Keywords:blood cell sorting, cotton thread
Subjects:Q Science > QR Microbiology
Divisions:Biosciences and Medical Engineering
ID Code:61176
Deposited By: Widya Wahid
Deposited On:15 Mar 2017 12:52
Last Modified:03 Aug 2017 11:43

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