The relationship between elasticity of polymeric gels and the in vitro release of medicaments

Abstract

Gels are semi-solid dosage forms that comprise small amount of solids dispersed in relatively large amount of liquid but still having solid-like structure. Rheological properties of gels may affect the release of proposed medicaments from the polymeric gels. The objective of this research was to find the relationship between the elasticity of polymeric gels and the in vitro release of Ketoconazole anti-fungal drug from different types of gel structures. Five types of gel bases were prepared, glycerin of starch, gelatin-glycerin, sodium carboxy methyl cellulose, Carbopol 934 and Eudragit L100. The rheological properties of gels were determined using Rheometer. Whereas the in vitro release of ketoconazole from the mentioned gel bases were determined using Franz Diffusion Cell. The results obtained showed that the higher the elasticity of the gel the more release of the drug.