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Docking study of b-glucosidase b (bglb) from p. polymyxca with cellobiose and cellotetrose

Ahmad Khairudin, Nurul bahiyah and Fadhilah Mazlan, Nur Shima (2014) Docking study of b-glucosidase b (bglb) from p. polymyxca with cellobiose and cellotetrose. Journal Of Medical And Bioengineering, 3 (2). pp. 78-83. ISSN 2301-3796

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Official URL: http://dx.doi.org/10.12720/jomb.3.2.78-83


Beta-glucosidase ( plays an essential role in the removal of non-reducing terminal glucosyl residues from sacharides and glycosides. Recently, beta-glucosidase has been of interest for biomass conversion that acts in synergy with two other enzymes, endo-glucanase and exo-glucanase. However, there is not much information regarding the molecular interactions of beta-glucosidase with cellobiose. Thus, this study reports on the binding modes between beta-glucosidase from glycoside hydrolase family 1 namely BglB with cellobiose and cellotetrose via molecular docking method. Further analysis on the hydrophobic interactions revealed the key residues involved in forming hydrogen bonds (h-bond) with the substrates. The active residue were identified to be Gln22, Glu167, Glu356, Glu402 and Trp402 .These findings may provide valuable insigths in designing beta-glucosidase with higher cellulose-hydrolyzing efficiency.

Item Type:Article
Subjects:A General Works
ID Code:59697
Deposited By: Haliza Zainal
Deposited On:23 Jan 2017 08:24
Last Modified:14 Jun 2017 15:55

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