Lim, M. M. and Sultana, N. (2015) Drug loading, drug release and in vitro degradation of poly(caprolactone) electrospun fibers. In: 2014 IEEE Conference on Biomedical Engineering and Sciences (IECBES), 8-10 Dec 2014, Kuala Lumpur, Malaysia.
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Official URL: http://www.dx.doi.org/10.1109/IECBES.2014.7047520
Abstract
In this study, model drug of Fluorescein Isothiocyanate-Dextran (FD70S) was incorporated into poly(caprolactone) (PCL) electrospun fibers. Drug loading was successful and drug release was measured by using microplate reader. The result showed FD70S was successfully released from PCL electrospun fibers. In order to investigate the biodegradable ability of PCL electrospun fibers, in vitro degradation was investigated for 107 days by immersing PCL electrospun fibers in phosphate buffer saline (PBS) which mimics extracellular fluid. Electrospun fibers degraded slowly and were not fully degraded. Fibers became more random and the average fiber diameters decreased from 350 nm to 240 nm after degradation of 107 days.
| Item Type: | Conference or Workshop Item (Paper) |
|---|---|
| Uncontrolled Keywords: | electrospun fibers, phosphate buffer saline |
| Subjects: | T Technology > TK Electrical engineering. Electronics Nuclear engineering |
| Divisions: | Electrical Engineering |
| ID Code: | 59230 |
| Deposited By: | Haliza Zainal |
| Deposited On: | 18 Jan 2017 01:50 |
| Last Modified: | 30 Aug 2021 17:32 |
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