DNA hybridization detection on porous silicon: A review

Abstract

In modern society, the application of biosensor gains its popularity in various fields such as biomedical diagnostic, food technology, cancer therapies, pharmaceutics and environmental monitoring. New biosensing technology is needed to accommodate low cost sensor, able to give fast response, versatile technique and eventually more stable products. During the past decades, various researches work focusing on how to immobilize biomolecules on compatible nanomaterial for the purpose of creating a sensing element. Among all of the nanomaterials that have been used, porous silicon (PS) exhibits great advantages on genetic research for instance the DNA detection. DNA based research became popular since the Genome Human Project (GHP) has been completed in year 2003. In this paper, the fabrication and properties of PS as a function of nanomaterial biosensing will be discussed especially for DNA detection application.