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Synthesis, characterization, in vitro bioactivity and antimicrobial activity of magnesium and nickel doped silicate hydroxyapatite

Alshemary, Ammar Z. and Akram, Muhammad and Goh, Yifan and Tariq, Usman and Butt, Faheem K. and Abdolahi, Ahmad and Hussain, Rafaqat (2015) Synthesis, characterization, in vitro bioactivity and antimicrobial activity of magnesium and nickel doped silicate hydroxyapatite. Ceramics Intertional, 41 (9). pp. 11886-11898. ISSN 2728-8421

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Official URL: http://dx.doi.org/10.1016/j.ceramint.2015.06.003

Abstract

Incorporation of Mg2+, Ni2+, and SiO44− ions into hydroxyapatite (HA) structure was successfully carried out by microwave assisted wet precipitation method to furnish Ca10−x−yMgxNiy(PO4)6−z(SiO4)z(OH)2−z□z. Incorporation of silicate ions into the HA structure led to the increase in HA lattice parameters, while incorporation of (Mg2+ and Ni2+) ions led to the reduction of lattice parameters and crystallite size of silicate doped HA. Optical analysis showed a distinct red shift upon increase in Ni2+ concentration due to the decrease in particle size. Dissolution of samples in simulated body fluid showed that the incorporation of Mg2+, Ni2+ and SiO44− in HA structure resulted in considerable increase in the in vitro dissolution of HA. The prepared samples promoted exceptional in vitro apatite growth over 14 days with Ca/P ratio close to 1.67. The analysis of in vitro antibacterial activity against E. coli and P. aeruginosa revealed that the Ni2+ containing samples possessed good antibacterial properties.

Item Type:Article
Uncontrolled Keywords:antibacterial activity, apatite, doping, in vitro bioactivity, silicate hydroxyapatite
Subjects:A General Works
ID Code:58874
Deposited By: Haliza Zainal
Deposited On:04 Dec 2016 12:07
Last Modified:20 Sep 2017 11:51

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