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Photobiostimulation effect on diabetic wound at different power density of near infrared laser

Lau, Pik Suan and Bidin, Noriah and Krishnan, Ganesan and AnaybBaleg, Sana Mohammed and Md. Sum, Mohamad and Bakhtiar, Hazri and Nassir, Zaleha and Hamid, Asmah (2015) Photobiostimulation effect on diabetic wound at different power density of near infrared laser. Journal Of Photochemistry And Photobiology B: Biology, 151 . pp. 201-207. ISSN 1011-1344

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Official URL: http://dx.doi.org/10.1016/j.jphotobiol.2015.08.009


The photobiostimulation effects of near infrared 808 nm diode laser irradiance on diabetic wound were investigated. 120 rats were induced with diabetes by streptozotocin injection. Full thickness punch wounds of 6 mm diameter were created on the dorsal part of the rats. All rats were randomly distributed into four groups; one group served as control group, whereas three groups were stimulated daily with unchanged energy density dose of 5 J/cm2 with different power density, which were 0.1 W/cm2, 0.2 W/cm2 and 0.3 W/cm2 with different exposure duration of 50 s, 25 s and 17 s, respectively. Ten rats from each group were sacrificed on day 3, 6 and 9, respectively. Skin tissues were removed for histological purpose. The contraction of wound was found optimized after exposure with 0.1 W/cm2. Based on the histological evidence, laser therapy has shown able to promote wound repair through enhanced epithelialization and collagen fiber synthesis. Generally, irradiated groups were advanced in terms of healing than non-irradiated group.

Item Type:Article
Uncontrolled Keywords:diabetic, diode laser, histological, photobiostimulation, therapy, wound healing
Subjects:A General Works
ID Code:58821
Deposited By: Haliza Zainal
Deposited On:04 Dec 2016 12:07
Last Modified:23 May 2017 09:38

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