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Overview of PES biocompatible/hemodialysis membranes: PES-blood interactions and modification techniques

Irfan, Muhammad and Ani, Idris (2015) Overview of PES biocompatible/hemodialysis membranes: PES-blood interactions and modification techniques. Materials Science & Engineering C-Materials For Biological Applications, 56 . pp. 574-592. ISSN 9284-931

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Official URL: http://dx.doi.org/10.1016/j.msec.2015.06.035

Abstract

Polyethersulfone (PES) based membranes are used for dialysis, but exposure to blood can result in numerous interactions between the blood elements and the membrane. Adsorption and transformation of plasma proteins, activation of blood cells, adherence of platelets and thrombosis reactions against PES membrane can invoke severe blood reactions causing the increase rate of mortality and morbidity of hemodialysis (HD) patients. In order to minimize blood immune response, different biomimetic, zwitterionic, non-ionic, anticoagulant molecules and hydrophilic brushes were immobilized or blended with PES polymers. These additives modified the nature of the membrane, enhanced their biocompatibility and also increased the uremic waste dialysis properties. In this review, current perspectives of the different additives which are used with PES are highlighted in relation with PES membrane-associated blood reactions. The additive's purpose, compatibility, preparation techniques, methods of addition to polymer and influence on the chemistry and performance of hemodialysis membranes are described.

Item Type:Article
Uncontrolled Keywords:additives, biocompatibility, coagulation, hemodialysis, hydrophilic brushes, PES
Subjects:A General Works
ID Code:58744
Deposited By: Haliza Zainal
Deposited On:04 Dec 2016 12:07
Last Modified:13 Apr 2017 11:47

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