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Optimising the production of succinate and lactate in Escherichia coli usingahybrid of artificial bee colony algorithm and minimisation of metabolic adjustment

Tang, Phooi Wah and Choon, Yee Wen and Mohamad, Mohd. Saberi and Deris, Safaai and Napis, Suhaimi (2015) Optimising the production of succinate and lactate in Escherichia coli usingahybrid of artificial bee colony algorithm and minimisation of metabolic adjustment. Journal of Bioscience and Bioengineering, 119 (3). pp. 363-368. ISSN 1389-1723

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Official URL: http://dx.doi.org/10.1016/j.jbiosc.2014.08.004

Abstract

Metabolic engineering is a research field that focuses on the design of models for metabolism, and uses computational procedures to suggest genetic manipulation. It aims to improve the yield of particular chemical or biochemical products. Several traditional metabolic engineering methods are commonly used to increase the production of a desired target, but the products are always far below their theoretical maximums. Using numeral optimisation algorithms to identify gene knockouts may stall at a local minimum in a multivariable function. This paper proposes a hybrid of the artificial bee colony (ABC) algorithm and the minimisation of metabolic adjustment (MOMA) to predict an optimal set of solutions in order to optimise the production rate of succinate and lactate. The dataset used in this work was from the iJO1366 Escherichia coli metabolic network. The experimental results include the production rate, growth rate and a list of knockout genes. From the comparative analysis, ABCMOMA produced better results compared to previous works, showing potential for solving genetic engineering problems.

Item Type:Article
Uncontrolled Keywords:escherichia coli, gene knockout, metabolic engineering, minimisation of metabolic adjustment
Subjects:Q Science > QA Mathematics > QA75 Electronic computers. Computer science
Divisions:Computing
ID Code:58715
Deposited By: Haliza Zainal
Deposited On:04 Dec 2016 04:07
Last Modified:05 Sep 2021 04:57

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