Rahim, M. A. and Ibrahim, W. A. W. and Ramli, Z. and Sanagi, M. M. (2015) New functionalised sol-gel hybrid sorbent coating for stir bar sorptive extraction of selected non-steroidal anti inflammatory drugs in human urine samples. Malaysian Journal Of Analytical Sciences, 19 (3). pp. 481-492. ISSN 1394-2506
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Abstract
A new sol-gel hybrid material, methyltrimethoxysilane-cyanopropyltriethoxysilane (MTMOS-CNPrTEOS) was successfully synthesized and used as a coating material in stir bar sorptive extraction (SBSE) of selected non-steroidal anti-inflammatory drugs (NSAIDs) in urine samples. The MTMOS-CNPrTEOS hybrid was synthesized by hydrolysis and condensation of MTMOS and CNPrTEOS in the presence of trifluoroacetic acid as catalyst via sol–gel method. Several factors influencing the synthesized sol-gel hybrid MTMOS-CNPrTEOS process such as mole ratio of MTMOS-CNPrTEOS, NaOH concentrations as etching solution, etching time, coating time and water content were investigated and optimized in this study. The optimum synthesis conditions obtained were 1:1 mol ratio of MTMOS-CNPrTEOS, 1 M NaOH as etching solution, 60 min etching time, 2 h coating time and 6 mmol water. The sol-gel hybrid MTMOS-CNPrTEOS synthesized under the optimum conditions was used to determine selected NSAIDs in human urine samples using normal stacking mode capillary electrophoresis with ultraviolet detection. MTMOS-CNPrTEOS SBSE method demonstrated good linearity (60 to 20,000 µg L-1) with excellent coefficient of determination (r2 > 0.9990). The sol-gel hybrid MTMOS-CNPrTEOS SBSE method showed low limit of detection (35 – 41 µg L-1) with good precision (RSD < 6 %, n = 3) and excellent extraction recoveries (83.5 – 98.9%) for the selected NSAIDs. The sol-gel hybrid MTMOS-CNPrTEOS SBSE method demonstrated good potential as an alternative sorbent in SBSE method for NSAIDs.
Item Type: | Article |
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Uncontrolled Keywords: | capillary electrophoresis-uv detection, non-steroidal anti-inflammatory drugs, normal stacking mode |
Subjects: | Q Science > QD Chemistry |
Divisions: | Science |
ID Code: | 58637 |
Deposited By: | Haliza Zainal |
Deposited On: | 04 Dec 2016 04:07 |
Last Modified: | 17 Dec 2021 07:37 |
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