Ong, S. B. and Kalkhoran, S. B. and Cabrera-Fuentes, H. A. (2015) Mitochondrial fusion and fission proteins as novel therapeutic targets for treating cardiovascular disease. European Journal Of Pharmacology, 763 . pp. 104-114. ISSN 0014-2999
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Official URL: http://dx.doi.org/10.1016/j.ejphar.2015.04.056
Abstract
The past decade has witnessed a number of exciting developments in the field of mitochondrial dynamics - a phenomenon in which changes in mitochondrial shape and movement impact on cellular physiology and pathology. By undergoing fusion and fission, mitochondria are able to change their morphology between elongated interconnected networks and discrete fragmented structures, respectively. The cardiac mitochondria, in particular, have garnered much interest due to their unique spatial arrangement in the adult cardiomyocyte, and the multiple roles they play in cell death and survival. In this article, we review the role of the mitochondrial fusion and fission proteins as novel therapeutic targets for treating cardiovascular disease.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | mitochondrial fission, mitochondrial fusion, OPA1 |
| Subjects: | Q Science > Q Science (General) |
| Divisions: | Biosciences and Medical Engineering |
| ID Code: | 58567 |
| Deposited By: | Haliza Zainal |
| Deposited On: | 04 Dec 2016 04:07 |
| Last Modified: | 07 Dec 2021 03:09 |
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