Universiti Teknologi Malaysia Institutional Repository

Microfluidic vascularized bone tissue model with hydroxyapatite-incorporated extracellular matrix

Jusoh, Norhana and Oh, Soo Jung and Kim, Su Dong and Kim, Jang Ho and Jeon, Noo li (2015) Microfluidic vascularized bone tissue model with hydroxyapatite-incorporated extracellular matrix. Lab On A Chip - Miniaturisation For Chemistry And Biology, 15 (20). pp. 3984-3988. ISSN 1473-0197

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Official URL: http://dx.doi.org/10.1039/c5lc00698h

Abstract

Current in vitro systems mimicking bone tissues fail to fully integrate the three-dimensional (3D) microvasculature and bone tissue microenvironments, decreasing their similarity to in vivo conditions. Here, we propose 3D microvascular networks in a hydroxyapatite (HA)-incorporated extracellular matrix (ECM) for designing and manipulating a vascularized bone tissue model in a microfluidic device. Incorporation of HA of various concentrations resulted in ECM with varying mechanical properties. Sprouting angiogenesis was affected by mechanically modulated HA-extracellular matrix interactions, generating a model of vascularized bone microenvironment. Using this platform, we observed that hydroxyapatite enhanced angiogenic properties such as sprout length, sprouting speed, sprout number, and lumen diameter. This new platform integrates fibrin ECM with the synthetic bone mineral HA to provide in vivo-like microenvironments for bone vessel sprouting.

Item Type:Article
Uncontrolled Keywords:Chemicals and CAS Registry Numbers: fibrin, 9001-31-4, hydroxyapatite, 1306-06-5, 51198-94-8, vasculotropin, 127464-60-2,Durapatite
Subjects:A General Works
ID Code:58546
Deposited By: Haliza Zainal
Deposited On:04 Dec 2016 12:07
Last Modified:26 Apr 2017 15:26

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