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Computer-Aided Approach for Designing Solvents Blend for Herbal Phytochemical Extraction

Mohammad Azmin, Siti Nuurul Huda and Yunus, Nor Alafiza and Mustaffa, Azizul Azri and Wan Alwi, Sharifah Rafidah and Lee, Suan Chua (2015) Computer-Aided Approach for Designing Solvents Blend for Herbal Phytochemical Extraction. Computer Aided Chemical Engineering, 37 . pp. 1427-1432. ISSN 1570-7946

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Official URL: http://dx.doi.org/10.1016/B978-0-444-63577-8.50083...


There are many methods to obtain herbs phytochemicals such as the use of solvents as a phytochemical transfer medium in the extraction process. Currently, solvent is preliminarily selected based on the target phytochemicals and solvent polarities. This is followed by performing experiments to determine the potential solvents blends which give the highest desired phytochemicals content. The method uses a trial-and-error approach and is time consuming as well as resource intensive. The combination of property predictive models with computer-assisted search is one way to reduce the needs for huge amount of experiments needed to be conducted. Thus, the main objective of this work is to design solvent blends for the extraction of herbal phytochemicals using computer-aided approach. The methodology is divided into four levels which are pure component constraints (level 1), linear constraints (level 2), non-linear constraints (level 3) and stability checks (level 4). The proposed method has been applied to design a solvent mixture for the extraction of kaempferol from Kacip Fatimah herb as a case study. From the analysis, 12 feasible binary solvents mixture have been identified to be suitable for the extraction as it was within range of the design target. Thus, the optimal search has been performed to find the mixture solvents that can produce the highest kaempferol extraction yield with the lowest cost. Here, five binary solvents showed the highest kaempferol yield with the lowest solvent cost.

Item Type:Article
Uncontrolled Keywords:herbal extraction, kacip fatimah, phytochemicals, product design, solvent blend
Subjects:A General Works
ID Code:58136
Deposited By: Haliza Zainal
Deposited On:04 Dec 2016 12:07
Last Modified:30 Aug 2017 11:46

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