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Barium and Fluorine Doped Synthetic Hydroxyapatite: Characterization and In-Vitro Bioactivity Analysis

Alshemary, Ammar Z. and Goh, Yi-Fan and Akram, Muhammad and Kadir, Mohammed Rafiq Abdul and Hussain, Rafaqat (2015) Barium and Fluorine Doped Synthetic Hydroxyapatite: Characterization and In-Vitro Bioactivity Analysis. Science Of Advanced Materials, 7 (2). pp. 249-257. ISSN 1944-7442

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Official URL: http://dx.doi.org/10.1166/sam.2015.2103


We have successfully doped hydroxyapatite (HA) with barium (Ba2+) and fluoride (F-) ions to furnish Ca10-xBax(PO4)6(OH)2-yFy, (where x = 0-1 and y = 1) by using microwave assisted wet precipitation method. The resulting powders were characterized by using X-ray diffraction (XRD), Fourier transform IR spectroscopy (FTIR), field-emission scanning electron microscopy (FESEM), energy-dispersive X-ray spectroscopy (EDX), Brunauer, Emmett and Teller (BET), and inductively coupled plasma optical emission spectrometry (ICP-OES) to study phase purity, particle morphology, elemental composition, specific surface area and in-vitro ion release. XRD analysis confirmed the formation of pure phase barium doped fluorine-hydroxyapatite with increased lattice parameters but with reduced degree of crystallinity. FESEM analysis confirmed the formation of spherical nanoparticles with homogenous distribution of elements with reduction in crystallite size when compared to HA, while BET results showed an increase in specific surface area upon increased degree of Ba doping. In-vitro bioactivity study carried out in SBF revealed that the incorporation of Ba2+ ions into HA structure lead to the faster release of Ca2+ ions resulting in faster formation of apatite layer.

Item Type:Article
Uncontrolled Keywords:apatite, doped hydroxyapatite, fluorine-hydroxyapatite, simulated body fluid, XRD
Subjects:A General Works
ID Code:57942
Deposited By: Haliza Zainal
Deposited On:04 Dec 2016 12:07
Last Modified:23 Feb 2017 13:10

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