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Antioxidant and α-glucosidase inhibitory constituents from Hornstedtia species of Malaysia

Hashim, S. E. and Sirat, H. M. and Yen, K. H. and Ismail, I. S. and Matsuki, S. N. (2015) Antioxidant and α-glucosidase inhibitory constituents from Hornstedtia species of Malaysia. tural Product Communications, 10 (9). pp. 1561-1563. ISSN 1934-578X

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Seven compounds were isolated from the n-hexane and chloroform extracts of the flowers and leaves of four Hornstedtia species and their structures were identified using spectroscopic techniques as 3,7,4'-trimethylkaempferol (1), 3,7-dimethylkaempferol (2), 7,4'-dimethylkaempferol (3), 3,5-dimethylkaempferol (4), 3-methylkaempferol (5), stigmast-4-en-3-one (6), and 6-hydroxy-stigmast-4-en-3-one (7). Compounds 1 to 7 were isolated from these species for the first time. They were assayed for free radical scavenging and α-glucosidase inhibition activities. The DPPH assay showed that 3-methylkaempferol (5) was the most potent antioxidant agent with an IC50 value 78.6 µM, followed by 7,4'-dimethylkaempferol (3) (IC50 = 86.1 µM). For α-glucosidase inhibition activity, 3-methylkaempferol (5) exhibited significant inhibitory activity with an IC50 value 21.0 µM. The present study revealed that Hornstedtia species have potential activities as antioxidant and α-glucosidase inhibitors.

Item Type:Article
Subjects:A General Works
ID Code:57843
Deposited By: Haliza Zainal
Deposited On:04 Dec 2016 12:08
Last Modified:06 Sep 2017 09:31

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