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Antioxidant and anti-cancer actvity of standardized extracts of three varieties of Ficus deltoidea’s leaves

Hanani Soib, Husnul and Ware, Ismail and Yaakob, Harisun and Mukrish, Hanafi and Sarmidi, Mohamad Roji (2015) Antioxidant and anti-cancer actvity of standardized extracts of three varieties of Ficus deltoidea’s leaves. Jurnal Teknologi, 77 (3). pp. 19-25. ISSN 0127-9696

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Official URL: http://dx.doi.org/10.11113/jt.v77.6000

Abstract

The present study was designed to evaluate the antioxidant and anti-cancer activities of aqueous extracts of three varieties of Ficus deltoidea (var. angustifolia, var. deltoidea, var. kunstleri) on prostate cancer DU145 cell line. The results showed that, F. deltoidea var. kunstleri contained the highest total phenolic (44.7 ± 0.022 mg GAE/10 g sample) and flavonoid contents (23.1 ± 0.005 mg CE/10 g sample) as well as the highest radical scavenging activity (IC50 0.039 mg/mL) followed by F. deltoidea var. deltoidea and F. deltoidea var. angustifolia. Similarly, based on anti-cancer activities, F. deltoidea var. kunstleri demonstrated the lowest IC50 value (93.11 ?g/mL) followed by F. deltoidea var. deltoidea (204.17 ?g/mL) and F. deltoidea var. angustifolia (429.54 ?g/mL). Other than that, vitexin which is a bioactive marker was appeared to be the highest in F. deltoidea var. kunstleri compared to others. Hence, the results suggested that there might be an association between antioxidant activities and bioactive markers against prostate cancer cell line (DU145).

Item Type:Article
Uncontrolled Keywords:anti-cancer, antioxidant, F. deltoidea
Subjects:A General Works
ID Code:57839
Deposited By: Haliza Zainal
Deposited On:04 Dec 2016 12:07
Last Modified:11 Apr 2017 08:41

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