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Antioxidant and alpha-Glucosidase Inhibitory Constituents from Hornstedtia Species of Malaysia

Hashim, Siti Ernieyanti and Sirat, Hasnah Mohd and Yen, Khong Heng and Ismail, Intan Safinar and Matsuki, Siti Nurulhuda (2015) Antioxidant and alpha-Glucosidase Inhibitory Constituents from Hornstedtia Species of Malaysia. Natural Product Communications, 10 (9). pp. 1561-1563. ISSN 1934-578X

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Seven compounds were isolated from the n-hexane and chloroform extracts of the flowers and leaves of four Hornstedtia species and their structures were identified using spectroscopic techniques as 3,7,4'-trimethylkaempferol (1), 3,7-dimethylkaempferol (2), 7,4'-dimethylkaempferol (3), 3,5-dimethylkaempferol (4), 3-methylkaempferol (5), stigmast-4-en-3-one (6), and 6-hydroxy-stigmast-4-en-3-one (7). Compounds 1 to 7 were isolated from these species for the first time. They were assayed for free radical scavenging and a-glucosidase inhibition activities. The DPPH assay showed that 3-methylkaempferol (5) was the most potent antioxidant agent with an IC50 value 78.6 µM, followed by 7,4'-dimethylkaempferol (3) (IC50 = 86.1 µM). For a-glucosidase inhibition activity, 3-methylkaempferol (5) exhibited significant inhibitory activity with an IC50 value 21.0 µM. The present study revealed that Hornstedtia species have potential activities as antioxidant and a-glucosidase inhibitors.

Item Type:Article
Uncontrolled Keywords:antioxidant, hornstedtia, zingiberaceae, a-glucosidase
Subjects:A General Works
ID Code:57838
Deposited By: Haliza Zainal
Deposited On:04 Dec 2016 12:07
Last Modified:11 Apr 2017 12:22

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