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Inhibitory effect of Artocarpus lowii King compounds on COX-2 and 15-LO activities

Mohamad Rosdi, Mohamad Norisham and Mohd. Sirat, Hasnah and Abdullah, Siti Awanis and Jamil, Shajarahtunnur and Muhamad, Ida Idayu and Mohamed Zulkifli, Razauden (2015) Inhibitory effect of Artocarpus lowii King compounds on COX-2 and 15-LO activities. Jurnal Teknologi, 76 (1). pp. 299-302. ISSN 2180-3722

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Official URL: http://dx.doi.org/10.11113/jt.v76.3652


Artocarpus lowii King is a rare species of plant in Moraceae family. In this study, the anti-inflammatory activity of cycloheterophyllin, isobavachalcone, 4-hydroxylonchocarpin and 2’,4’-dihydroxy-4-methoxy-3’-prenyldihydroxychalcone isolated from A. lowii King were investigated on classical enzymes in arachidonic acid metabolism pathways; cyclooxygenase and lipoxygenase. Isobavachalcone directly inhibited cyclooxygenase-2 enzyme in dose dependent manner, with IC50 value of 0.95 µM. No noticeable effect has been observed with the other tested compounds. In addition, none of the tested compounds displays a direct inhibition on 15-lipoxygenase when compared to the resveratrol as control with the IC50 value of 1.5 µM. Isobavachalcone showed inhibitory effect on cyclooxygenase-2. This study suggests that A. lowii King contains potential anti-inflammatory activity

Item Type:Article
Uncontrolled Keywords:cyclooxygenase-2, isobavachalcone
Subjects:R Medicine > R Medicine (General)
Divisions:Biosciences and Medical Engineering
ID Code:55960
Deposited By: Fazli Masari
Deposited On:15 Nov 2016 06:24
Last Modified:01 Nov 2017 04:16

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