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Heterocyclic scaffolds: centrality in anticancer drug development

Ali, Imran and Lone, Mohammad Nadeem and Al-Othman, Zeid Abdullah and Al-Warthan, Abdulrahman and Sanagi, Mohd. Marsin (2015) Heterocyclic scaffolds: centrality in anticancer drug development. Current Drug Targets, 6 (7). pp. 711-734. ISSN 1389-4501

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Abstract

Cancer has been cursed for human beings for long time. Millions people lost their lives due to cancer. Despite of the several anticancer drugs available, cancer cannot be cured; especially at the late stages without showing any side effect. Heterocyclic compounds exhibit exciting medicinal properties including anticancer. Some market selling heterocyclic anticancer drugs include 5-flourouracil, methortrexate, doxorubicin, daunorubicin, etc. Besides, some natural products such as vinblastine and vincristine are also used as anticancer drugs. Overall, heterocyclic moeities have always been core parts in the expansion of anticancer drugs. This article describes the importance of heterocyclic nuclei in the development of anticancer drugs. Besides, the attempts have been made to discuss both naturally occurring and synthetic heterocyclic compounds as anticancer agents. In addition, some market selling anticancer heterocyclic compounds have been described. Moreover, the efforts have been made to discuss the mechanisms of actions and recent advances in heterocyclic compounds as anticancer agents. The current challenges and future prospectives of heterocyclic compounds have also been discussed. Finally, the suggestions for syntheses of effective, selective, fast and human friendly anticancer agents are discussed into the different sections

Item Type:Article
Uncontrolled Keywords:future prospectives, heterocyclic compounds
Subjects:Q Science > QD Chemistry
Divisions:Science
ID Code:55564
Deposited By: Fazli Masari
Deposited On:19 Sep 2016 04:55
Last Modified:15 Feb 2017 04:36

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