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Evidences of in vivo bioactivity of Fe-bioceramic composites for temporary bone implants

Ulum, Mokhamad Fakhrul and Nasution, Ahmad Kafrawi and Md. Yusop, Abdul Hakim and Arafat, Andril and Abdul Kadir, Mohammed Rafiq and Juniantito, Vetnizah and Noviana, Deni and Hermawan, Hendra (2015) Evidences of in vivo bioactivity of Fe-bioceramic composites for temporary bone implants. Journal of Biomedical Materials Research - Part B Applied Biomaterials, 103 (7). pp. 1354-1365. ISSN 1552-4973

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Official URL: http://dx.doi.org/10.1002/jbm.b.33315


Iron-bioceramic composites have been developed as biodegradable implant materials with tailored degradation behavior and bioactive features. In the current work, in vivo bioactivity of the composites was comprehensively studied by using sheep animal model. Five groups of specimens (Fe-HA, Fe-TCP, Fe-BCP composites, and pure-Fe and SS316L as controls) were surgically implanted into medio proximal region of the radial bones. Real-time ultrasound analysis showed a decreased echo pattern at the peri-implant biodegradation site of the composites indicating minimal tissue response during the wound healing process. Peripheral whole blood biomarkers monitoring showed a normal dynamic change of blood cellular responses and no stress effect was observed. Meanwhile, the released Fe ion concentration was increasing along the implantation period. Histological analysis showed that the composites corresponded with a lower inflammatory giant cell count than that of SS316L. Analysis of the retrieved implants showed a thicker degradation layer on the composites compared with pure-Fe. It can be concluded that the iron-bioceramic composites are bioactive and induce a preferable wound healing process. © 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 103B: 1354-1365, 2015.

Item Type:Article
Uncontrolled Keywords:bioactive, bioceramics, biodegradable metals
Subjects:R Medicine > R Medicine (General)
Divisions:Biosciences and Medical Engineering
ID Code:55126
Deposited By: Fazli Masari
Deposited On:11 Aug 2016 09:15
Last Modified:15 Feb 2017 07:39

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