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Evaluation of pharmaceutical cream production debottlenecking schemes

Tan, Jully and Foo, Dominic Chwan Yee and Kumaresan, Sivakumar and Abdul Aziz, Ramlan (2005) Evaluation of pharmaceutical cream production debottlenecking schemes. In: International Symposium On Design, Operation and Control Of Chemical Processes 2005, 13-15 August 2005, Seoul, Korea.



The main objective of this work is to model and debottleneck a pharmaceutical production of an anti-allergic cream. The base case process has a minimum cycle time of 29 hours which is equivalent to 66 batches/year. Four schemes were proposed for process debottlenecking due to the anticipated increase of the product demand of 150% in the market. By carrying out throughput analysis study, schemes that fulfil the debottlenecking objective were determined. Out of the four debottlenecking schemes, Scheme 4 was chosen, which proposed a new blending tank and intermediate tank, showed a production increase of over 150%.

Item Type:Conference or Workshop Item (Paper)
Uncontrolled Keywords:Batch, modelling, optimisation, throughput, scheduling
Subjects:T Technology > T Technology (General)
Divisions:Chemical and Natural Resources Engineering
ID Code:5366
Deposited By: Norhani Jusoh
Deposited On:31 Mar 2008 09:09
Last Modified:01 Jun 2010 15:29

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