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Fabrication of Nanohydroxyapatite/Poly(caprolactone) composite microfibers using electrospinning technique for tissue engineering applications

Hassan, Mohd. Izzat and Sun, Tao and Sultana, Naznin (2014) Fabrication of Nanohydroxyapatite/Poly(caprolactone) composite microfibers using electrospinning technique for tissue engineering applications. Journal of Nanomaterials . ISSN 1687-4110

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Official URL: http://dx.doi.org/10.1155/2014/209049

Abstract

Tissue engineering fibrous scaffolds serve as three-dimensional (3D) environmental framework by mimicking the extracellular matrix (ECM) for cells to grow. Biodegradable polycaprolactone (PCL) microfibers were fabricated to mimic the ECM as a scaffold with 7.5% (w/v) and 12.5% (w/v) concentrations. Lower PCL concentration of 7.5% (w/v) resulted in microfibers with bead defects. The average diameter of fibers increased at higher voltage and the distance of tip to collector. Further investigation was performed by the incorporation of nanosized hydroxyapatite (nHA) into microfibers. The incorporation of 10% (w/w) nHA with 7.5% (w/v) PCL solution produced submicron sized beadless fibers. The microfibrous scaffolds were evaluated using various techniques. Biodegradable PCL and nHA/PCL could be promising for tissue engineering scaffold application.

Item Type:Article
Uncontrolled Keywords:average diameter, electrospinning techniques, extracellular matrices, fibrous scaffolds
Subjects:Q Science > QH Natural history
Divisions:Biosciences and Medical Engineering
ID Code:52848
Deposited By: Siti Nor Hashidah Zakaria
Deposited On:01 Feb 2016 11:53
Last Modified:04 Jul 2018 19:52

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