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Cytotoxic activities against breast cancer cells of local justicia gendarussa crude extracts

Ayob, Zahidah and Mohd. Bohari, Siti Pauliena and Abd. Samad, Azman and Jamil, Shajarahtunnur (2014) Cytotoxic activities against breast cancer cells of local justicia gendarussa crude extracts. Evidence-Based Complementary and Alternative Medicine . ISSN 1741-427X

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Official URL: http://dx.doi.org/10.1155/2014/732980

Abstract

Justicia gendarussa methanolic leaf extracts from five different locations in the Southern region of Peninsular Malaysia and two flavonoids, kaempferol and naringenin, were tested for cytotoxic activity. Kaempferol and naringenin were two flavonoids detected in leaf extracts using gas chromatography-flame ionization detection (GC-FID). The results indicated that highest concentrations of kaempferol and naringenin were detected in leaves extracted from Mersing with 1591.80 mg/kg and 444.35 mg/kg, respectively. Positive correlations were observed between kaempferol and naringenin concentrations in all leaf extracts analysed with the Pearson method. The effects of kaempferol and naringenin from leaf extracts were examined on breast cancer cell lines (MDA-MB-231 and MDA-MB-468) using MTT assay. Leaf extract from Mersing showed high cytotoxicity against MDA-MB-468 and MDA-MB-231 with ICvalues of 23 g/mL and 40 g/mL, respectively, compared to other leaf extracts. Kaempferol possessed high cytotoxicity against MDA-MB-468 and MDA-MB-231 with ICvalues of 23 g/mL and 34 g/mL, respectively. These findings suggest that the presence of kaempferol in Mersing leaf extract contributed to high cytotoxicity of both MDA-MB-231 and MDA-MB-468 cancer cell lines

Item Type:Article
Uncontrolled Keywords:justicia gendarussa extract, kaempferol, methanol, naringenin, plant extract, tamoxifenun, classified drug
Subjects:Q Science > QH Natural history
R Medicine > R Medicine (General)
Divisions:Biosciences and Medical Engineering
ID Code:52280
Deposited By: Siti Nor Hashidah Zakaria
Deposited On:01 Feb 2016 11:54
Last Modified:17 Sep 2018 12:01

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