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Antioxidant activities and tyrosinase inhibition effects of Phaleria macrocarpa extracts

Nadri, Muhammad Helmi and Salim, Yushatika and Basar, Norazah and Yahya, Azli and Zulkifli, Razauden Mohamed (2014) Antioxidant activities and tyrosinase inhibition effects of Phaleria macrocarpa extracts. African Journal of Traditional Complementary and Alternative Medicines, 11 (3). pp. 107-111. ISSN 0189-6016

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Official URL: http://dx.doi.org/10.4314/ajtcam.v11i3.16

Abstract

BACKGROUND: The ethyl acetate and chloroform extracts of stems, leaves and fruits of Phaleria macrocarpa were screened for their antioxidant capacity and tyrosinase inhibition properties. MATERIAL AND METHOD: The total phenolic content (TPC), 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging and ferric-ion reducing power (FRAP) were used to evaluate their antioxidant capacity. Tyrosinase inhibition effect was measured using mushroom tyrosinase inhibition assay. RESULT: Ethyl acetate extract of P. macrocarpa's stem exhibited highest total phenolic content, DPPH free radical scavenging and ferric reducing power. Meanwhile, chloroform extracts of leaves and fruits demonstrated potent anti-tyrosinase activities as compared to a well-known tyrosinase inhibitor, kojic acid. CONCLUSION: Since chloroform extracts of leaves and fruits have low antioxidant capacities, the tyrosinase inhibition effect observed are antioxidant independent. This study suggests direct tyrosinase inhibition by chloroform extracts of Phaleria macrocarpa.

Item Type:Article
Uncontrolled Keywords:Phaleria macrocarpa, antioxidant, total phenolic content, tyrosinase inhibition
Subjects:Q Science
Divisions:Science
ID Code:51875
Deposited By: Siti Nor Hashidah Zakaria
Deposited On:01 Feb 2016 11:53
Last Modified:09 Nov 2018 16:29

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