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Cytotoxic activity of major compounds from phaleria macrocarpa (scheff.) Boerl. Fruits

Md. Othman, Siti Nur Atiqah and Basar, Norazah and Mohd. Bohari, Siti Pauliena (2013) Cytotoxic activity of major compounds from phaleria macrocarpa (scheff.) Boerl. Fruits. Jurnal Teknologi (Sciences and Engineering), 64 (2). pp. 53-56. ISSN 0127-9696

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Official URL: http://dx.doi.org/10.11113/jt.v64.2044

Abstract

P. macrocarpa is a well known Indonesian medicinal plant which is traditionally claimed to have anticancer properties. To date, there are numerous cytotoxic studies conducted on crude extracts of this plant. However, there are limited informations available regarding cytotoxic activity of the compounds isolated from this plant. Thus, this study investigated cytotoxic activity of two benzophenones derivatives identified as 2,6,4'-trihydroxy-4-methoxybenzophenone (1) and 6,4'-dihydroxy-4-methoxybenzophenone-2-O-β-D-glucopyranoside (2) isolated from the ethyl acetate extract. Cytotoxic activities of these compounds were performed against human cervical carcinoma cell line (HeLa) and mouse embryonic fibroblast cell line (3T3) using MTT assay. The result showed that benzophenone (1) exhibited low cytotoxic effect against HeLa and 3T3 cell lines with IC50 values of 132 µg/ml and 158 µg/ml, repectively while benzophenone (2) was non toxic against HeLa and 3T3 cell lines are because the IC50 is more than 250 µg/ml. These findings may sheds light on the actual properties of this plant

Item Type:Article
Uncontrolled Keywords:P. macrocarpa, benzophenones, cytotoxic, MTT, HeLa, 3T3
Subjects:Q Science > QD Chemistry
Divisions:Science
ID Code:50002
Deposited By: Siti Nor Hashidah Zakaria
Deposited On:02 Dec 2015 10:09
Last Modified:27 Sep 2018 12:09

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