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Bioactivities and cytotoxicities effects of 3',4'-dihydroxy-7-methoxyflavone and 2'-hydroxy-3,4,3',4'-tetramethoxychalcone

Ahmad, N. A. and Nordin, N. H. and Nadri, Muhammad Helmi and Mohamed Zulkifli, Razauden and Ahmad, Farediah and Mohd. Sirat, Hasnah (2013) Bioactivities and cytotoxicities effects of 3',4'-dihydroxy-7-methoxyflavone and 2'-hydroxy-3,4,3',4'-tetramethoxychalcone. Advanced Science Letters, 19 (12). pp. 3628-3631. ISSN 1936-6612

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Official URL: http://dx.doi.org/10.1166/asl.2013.5218


Synthetic compounds 3',4'-dihydroxy-7-methoxyflavone (DHMF) and 2'-hydroxy-3,4,3',4'-tetramethoxychalcone (HTMC) were investigated for their antioxidant and anti-tyrosinase activities. Antioxidant activities were evaluated by using 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging and Ferric Reducing Ability of Plasma (FRAP) assay. DHMF possessed antioxidant activities with no activity detected for HTMC. Further investigation demonstrates that DHMF possessed greater antioxidant capacity at longer incubation time compared to L-ascorbic acid. In contrast, HTMC demonstrates a novel anti-tyrosinase activity with no activity observed for DHMF. Evaluation on cytotoxicity effects revealed that both synthetic compounds inhibit the viability of CHO and HeLa cells in a concentration-dependent manner with no effect detected at low concentration.

Item Type:Article
Uncontrolled Keywords:2'-hydroxy-3, 3', 3',4'-dihydroxy-7-methoxyflavone, 4, 4'-tetramethoxychalcone, bioactivity effect, cytotoxicity effect
Subjects:Q Science > QP Physiology
ID Code:49497
Deposited By: Siti Nor Hashidah Zakaria
Deposited On:02 Dec 2015 02:09
Last Modified:30 Nov 2018 06:55

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