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Cox-2 inhibitors from stem bark of Bauhinia rufescens lam. (Fabaceae)

Mohd. Sirat, Hasnah and Muhammad, Aminu (2013) Cox-2 inhibitors from stem bark of Bauhinia rufescens lam. (Fabaceae). EXCLI Journal, 12 . pp. 824-830. ISSN 1611-2156

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Abstract

Chemical investigation of the stem bark of Bauhinia rufescens resulted in the isolation of a new cyanoglucoside and menisdaurin from methanol extract and oxepin from petroleum ether extract. The isolated compounds were tested for their anti-inflammatory potentials based on the cyclooxygenase-2 enzyme (COX-2) model. Cyanoglucoside exhibited the highest activity among the compounds with an inhibition activity of 49.34% at 100 μM (IC50 0.46 μM) compared to the positive control, indomethacin (79.20%, IC50 0.24 μM)

Item Type:Article
Uncontrolled Keywords:Bauhinia rufescens, COX-2, phytochemicals
Subjects:Q Science > Q Science (General)
Divisions:Science
ID Code:49079
Deposited By: Siti Nor Hashidah Zakaria
Deposited On:02 Dec 2015 10:08
Last Modified:27 Sep 2018 12:07

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