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Application of dispersive liquid-liquid microextraction based on solidification of floating organic droplet to the analysis of antidepressant drugs in water samples

Sanagi, Mohd. Marsin and Mokhtar, Siti Umairah and Wan Ibrahim, Wan Aini and Aboul Enein, Hassan Y. (2013) Application of dispersive liquid-liquid microextraction based on solidification of floating organic droplet to the analysis of antidepressant drugs in water samples. Sains Malaysiana, 42 (2). pp. 149-157. ISSN 0126-6039

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Official URL: http://www.ukm.my/jsm/

Abstract

A simple and rapid sample preparation method based on dispersive liquid-liquid microextraction-solidification of floating organic drop (DLLME-SFO) combined with gas chromatography-mass spectrometry (GC-MS) method was developed for the analysis of antidepressant drugs in water samples. This method uses organic solvent with low density and less toxicity. In the method, the disperser solvent (0.5 mL acetonitrile) containing 30 μL of n-hexadecane was rapidly injected using a syringe into 5.0 mL of water sample in a glass tube. After centrifugation for 7 min at 3,500 rpm, the mixture was cooled in ice bath for 5 min. The solidified n-hexadecane was transferred into a conical vial, where it melted rapidly at room temperature and 2 μL of it was injected into a gas Chromatograph for analysis. Under optimized conditions, the method showed good linearity in the range of 0.04 - 0.12 μg mL1 for amitriptyline and chlorpromazine with correlation of determination (r 2) in the range of 0.992 - 0.995. The limits of detections (LODs) were in the range 0.0085 - 0.0285 μg mL-1. The extraction recoveries of amitriptyline and chlorpromazine from water samples at spiking level of 0.08 μg mL-1 were 71.34 - 73.52% and 73.83 - 91.09%, respectively, with relative standard deviations (RSDs) in the range of 4.97-6.85% for amitriptyline and 4.84 - 7.49% for chlorpromazine. The method was successfully applied to the determination of the analytes in drinking water, lake water and tap water samples.

Item Type:Article
Uncontrolled Keywords:antidepressant drugs, gas chromatography-mass spectrometry, water samples
Subjects:Q Science
Divisions:Science
ID Code:49014
Deposited By: Siti Nor Hashidah Zakaria
Deposited On:02 Dec 2015 10:09
Last Modified:09 Nov 2018 16:11

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