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Mechanical and functional assessment of the wrist affected by rheumatoid arthritis: a finite element analysis

Bajuri, M. N. and Kadir, M. R. and Raman, M. M. and Kamarul, T. (2012) Mechanical and functional assessment of the wrist affected by rheumatoid arthritis: a finite element analysis. Medical Engineering And Physics, 34 (9). pp. 1294-1302. ISSN 1350-4533

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Official URL: http://dx.doi.org/10.1016/j.medengphy.2011.12.020

Abstract

Understanding the pathomechanics involved in rheumatoid arthritis (RA) of the wrist provides valuable information, which will invariably allow various therapeutic possibilities to be explored. The computational modelling of this disease permits the appropriate simulation to be conducted seamlessly. A study that underpins the fundamental concept that produces the biomechanical changes in a rheumatoid wrist was thus conducted through the use of finite element method. The RA model was constructed from computed tomography datasets, taking into account three major characteristics: synovial proliferation, cartilage destruction and ligamentous laxity. As control, a healthy wrist joint model was developed in parallel and compared. Cartilage was modelled based on the shape of the articulation while the ligaments were modelled with linear spring elements. A load-controlled analysis was performed simulating physiological hand grip loading conditions. The results demonstrated that the diseased model produced abnormal wrist extension and stress distribution as compared to the healthy wrist model. Due to the weakening of the ligaments, destruction of the cartilage and lower bone density, the altered biomechanical stresses were particularly evident at the radioscaphoid and capitolunate articulations which correlate to clinical findings. These results demonstrate the robust finding of the developed RA wrist model, which accurately predicted the pathological process.

Item Type:Article
Uncontrolled Keywords:RA wrist model, rheumatoid arthritis , synovial proliferation
Subjects:R Medicine > RC Internal medicine
Divisions:Biosciences and Medical Engineering
ID Code:47190
Deposited By: Narimah Nawil
Deposited On:22 Jun 2015 13:56
Last Modified:31 Mar 2019 16:34

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