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CMD: a database to store the bonding states of cysteine motifs with secondary structures

Bostan, Hamed and Salim, Naomie and Hussein, Zeti Azura and Klappa, Peter and Sahmsir, Mohd. Shahir (2012) CMD: a database to store the bonding states of cysteine motifs with secondary structures. Advances in Bioinformatics . pp. 1-5. ISSN 1687-8027


Official URL: http://dx.doi.org/10.1155/2012/849830


Computational approaches to the disulphide bonding state and its connectivity pattern prediction are based on various descriptors. One descriptor is the amino acid sequence motifs flanking the cysteine residue motifs. Despite the existence of disulphide bonding information in many databases and applications, there is no complete reference and motif query available at the moment. Cysteine motif database (CMD) is the first online resource that stores all cysteine residues, their flanking motifs with their secondary structure, and propensity values assignment derived from the laboratory data. We extracted more than 3 million cysteine motifs from PDB and UniProt data, annotated with secondary structure assignment, propensity value assignment, and frequency of occurrence and coefficiency of their bonding status. Removal of redundancies generated 15875 unique flanking motifs that are always bonded and 41577 unique patterns that are always nonbonded. Queries are based on the protein ID, FASTA sequence, sequence motif, and secondary structure individually or in batch format using the provided APIs that allow remote users to query our database via third party software and/or high throughput screening/querying. The CMD offers extensive information about the bonded, free cysteine residues, and their motifs that allows in-depth characterization of the sequence motif composition.

Item Type:Article
Uncontrolled Keywords:Bioinformatics
Subjects:Q Science > QH Natural history
Divisions:Computer Science and Information System (Formerly known)
ID Code:46694
Deposited By: Haliza Zainal
Deposited On:22 Jun 2015 13:56
Last Modified:18 Sep 2017 12:04

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