Bioactive polymer scaffold for fabrication of vascularized engineering tissue

Sukmana, I. (2012) Bioactive polymer scaffold for fabrication of vascularized engineering tissue. Journal of Artificial Organs, 15 (3). pp. 215-224. ISSN 1434-7229

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Tissue engineering seeks strategies to design polymeric scaffolds that allow high-cell-density cultures with signaling molecules and suitable vascular supply. One major obstacle in tissue engineering is the inability to create thick engineered-tissue constructs. A pre-vascularized tissue scaffold appears to be the most favorable approach to avoid nutrient and oxygen supply limitations as well as to allow waste removal, factors that are often hurdles in developing thick engineered tissues. Vascularization can be achieved using strategies in which cells are cultured in bioactive polymer scaffolds that can mimic extracellular matrix environments. This review addresses recent advances and future challenges in developing and using bioactive polymer scaffolds to promote tissue construct vascularization.

Item Type:Article
Uncontrolled Keywords:Artificial organs
Subjects:R Medicine > RD Surgery
Divisions:Biosciences and Medical Engineering
ID Code:46650
Deposited By: Haliza Zainal
Deposited On:22 Jun 2015 13:56
Last Modified:17 Sep 2017 16:57

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